USC Salkehatchie is a two-year regional campus of the University of South Carolina serving Allendale and Walterboro, South Carolina, offering associate degrees and 2+2 transfer pathways into four-year programs. The campus offers a 2+2 Bachelor of Science in Industrial Process Engineering in partnership with USC Aiken, providing rural students access to an engineering degree by completing two years locally before transferring. Associate degrees in foundational sciences support transfer into STEM programs at USC's four-year campuses, including pathways into engineering, biology, and mathematics. Palmetto College online bachelor's programs in Engineering Technology Management and Applied Computer Science with Cybersecurity extend the campus's technology credential offerings statewide. USC Salkehatchie's dual-campus structure in Allendale and Walterboro provides critical higher education access to two of South Carolina's most rural and underserved counties.

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