The University of South Dakota is the state's flagship comprehensive university located in Vermillion, South Dakota, offering over 200 undergraduate and the largest selection of graduate programs in the state. Computer Science programs are offered at the bachelor's level with specializations in Artificial Intelligence, and at the master's level through dedicated MS tracks. Graduate STEM programs include M.S. Artificial Intelligence, M.S. Computer Science, M.S. Mathematics, M.S. Physics, M.S. Chemistry, and a collaborative Ph.D. in Data Science and Engineering with SD Mines. The Beacom School of Business provides MBA programs with specializations in AI, Business Analytics, Operations and Supply Chain Management, and Sustainability. USD's Vermillion campus anchors the state's graduate science ecosystem, with strong ties to biomedical, computational, and data-driven research communities.

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